Oxeia Biopharma in the News
Concussion Drug Therapies on the Horizon
Michael Wyand, PhD, Chief Executive Officer/Director, Oxeia Biopharmaceuticals explains why there’s a need for new drugs to treat traumatic brain injuries. Page 6-7
Game on for Concussion Therapies
Most concussions—mild traumatic brain injuries (TBIs)—aren’t treated. Only a fraction of people who experience concussions seek help, and those who do usually are only prescribed rest. For about 20 percent, however, rest doesn’t alleviate the symptoms. Those symptoms may persist for months or years, making daily life difficult. As yet, there is no FDA-approved treatment for mild TBI.
KU Medical Center researcher testing drug to improve concussion symptoms
KU Medical Center researcher testing drug to improve concussion symptoms.
Drug tested in pilot study showed promising results in reducing common concussion symptoms.
CONCUSSION DRUG STUDY SHOWS POSITIVE EARLY RESULTS
CONCUSSION DRUG STUDY SHOWS POSITIVE EARLY RESULTS
Study showed improvement in concussion symptoms in participants receiving OXE103.
OXE103 pilot Phase 2a trial shows strong potential as an effective treatment for concussion.
The OXE103 responder rate was 85% vs. a baseline of 33%.
OXE103 is first in class investigational drug to potentially treat underlying neuro-metabolic and axonal injury in concussion.
There are currently few studies for and no effective pharmacological FDA-approved treatments for concussion.
The injection of Ghrelin (OXE-103) improves subacute concussion symptom burden and quality of life
A Ph2a Concussion study of Oxeia Biopharmaceutical’s drug, OXE103, showed strong potential as an effective concussion treatment. Dr. Michael Rippee of KUMC Medical Center presented the findings during the ACRM Conference on 10/31
A tough puzzle: complexity slows drug development for concussions
Condition heterogeneity warrants multiple therapeutic approaches, but past failures highlight developmental challenges.
Roll Call: We need more than brain injury awareness: We need new treatment
Over $76 billion — that’s the total direct and indirect costs of traumatic brain injuries (TBI) annually. And that’s just the tip of the iceberg.
There are 611 TBI-related hospitalizations and 176 TBI-related deaths each day in the United States. Even more traumatic brain injuries go untreated, with many of those Americans facing injury unable to access medical care.
Why Are We Failing Veterans Who Bravely Served Our Country?
There is no simple solution, but more attention must be focused on not only understanding why the suicide prevention programs aren’t working, but also developing dramatically improved detection, prevention, and treatment programs and therapies for soldiers.
As part of this equation, we must continue to examine the link between traumatic brain injuries (TBIs) – including mild TBIs (mTBIs) or concussion – and increased risk for suicide. Of the almost 459,000 service members diagnosed with a TBI worldwide between 2000 and Q1 2022, over 82 percent had concussions.
Phase 2 Trial of OXE103 in Concussion Reports Positive Interim Progress
NeurologyLive - Phase 2 Trial of OXE103 in Concussion Reports Positive Interim Progress. The investigational therapy is a twice-daily injectable identical formulation of the protein ghrelin, being assessed in a 2-part trial including individuals who are highly symptomatic within 28 days of brain injury.
OXEIA ANNOUNCES POSITIVE INTERIM RESULTS OF PHASE 2 TRIAL FOR OXE103 FOR THE TREATMENT OF CONCUSSIONS
August 3, 2022 (Boston) – Oxeia Biopharmaceuticals Inc., a clinical stage biotech company developing a drug treatment for concussion to address underlying neuro-metabolic dysfunction and axonal injury, announced today the completion of an interim analysis of its ongoing Phase 2 clinical trial of OXE103 at the University of Kansas Medical Center.
Talking About Oxeia’s Phase 2 Clinical Trial for Concussion with Brain Injury Radio Host Kim Justus
Oxeia's CEO Dr. Michael Wyand talked about what happens in your brain when you have a concussion and how his company’s therapeutic, OXE103, now being tested in humans could potentially treat concussions by addressing underlying neuro-metabolic dysfunction and axonal injury. Dr. Wyand and Kim Justus encouraged people in the Kansas City market that have had a concussion in the past 28 days to visit restisnotenough.com to see if they are eligible to participate in the trial to help advance brain injury research.
C'mon Congress — it's time to take the brain injury epidemic seriously
Rebeccah Wolfkiel, the Executive Director of the National State Association of State Head Injury Administrators & Oxeia CEO, Michael Wyand urge Congress to prioritize funding for federal programs that support both civilians and military personnel living with brain injuries and for finding effective treatments for TBI.
You don’t have to be knocked out to get a concussion. Help KU Med find new treatments
Kansas City area residents concussed in the past 28 days and experiencing concussion symptoms invited to "break barriers to better brain health by participating in a phase 2 clinical trial at KU Medical Center.”
OXEIA BIOPHARMACEUTICALS ANNOUNCES NEW BOARD AND MANAGEMENT TEAM MEMBERS AND RELOCATES CORPORATE HEADQUARTERS TO BOSTON
Boston, MA, January 20, 2022 – Oxeia Biopharmaceuticals, a clinical stage biotech company conducting Phase 2 clinical trials of OXE103 for treating concussion, today announced two new board members and additions to its executive leadership team. The company also announced its corporate headquarters’ move from San Diego to Boston.
KANSAS CITY AREA RESIDENTS ASKED TO PARTICIPATE IN PHASE 2 TRIAL OF OXE103
BOSTON, MA (December 21, 2021) – Oxeia Biopharmaceuticals Inc., a clinical stage biotech company developing a drug treatment for concussion to address underlying neuro-metabolic dysfunction and axonal injury is actively recruiting participants for its ongoing Phase 2 clinical trial of OXE103 at the University of Kansas Medical Center. OXE103 could advance treatment directly addressing the underlying pathology of concussion (mTBI). The program seeks qualified volunteers from the Kansas City area to participate in this study, which could help people with continued symptoms after sustaining a concussion.
The Defense Post: Veterans Have More to Fear from Mild Traumatic Brain Injuries than Expected
Writing in support of the TBI and PTSD Law Enforcement Training Act, Dr. Michael Wyand, CEO of Oxeia Biopharmaceuticals, calls for adding funding to the bill for finding an effective treatment for concussion.
Public Service Announcement: Phase 2 clinical trial for Oxeia’s concussion drug, OXE103
The Center for Concussion Management at the University of Kansas Health System, in partnership with the University of Kansas Medical Center, is looking for volunteers for a new concussion treatment research study.
Oxeia CEO Michael Wyand participated in OneNucleus BioWednesday Webinar: Prevention vs. Cure
If you can’t remove all risk can you at least treat the outcome? This session included a discussion of Oxeia’s concussion drug, OXE103, which is in Phase 2 clinical trials. Click “Read More” to watch the video.
“I became an advisor to Oxeia to contribute to an action that could change the face of how concussions are treated. Wouldn’t it be great if football players, hockey players and boxers, among others, could play their sport without the constant worry of repercussions from getting walloped in the head? Oxeia’s progress toward the delivery of a treatment for concussions fills me with great excitement about the future of sports.”
Richard Sherman
Cornerback for the San Francisco 49ers and
Advisory Board Member, Oxeia Biopharmaceuticals